October 21, 2005Biochemistry

Thrombomodulin Tightens the Thrombin Active Site Loops To Promote Protein C Activation

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Population

In vitro biochemical model of thrombin

Comparison

Active thrombomodulin fragment (TMEGF45) vs Inactive thrombomodulin fragment (TMEGF56)

Design

Preclinical

Authors

JKJulia R. KoeppeState University of New York at Oswego ASAlmagoul Seitova TMTimothy MatherUniversity of North Carolina at Chapel Hill

Discussion

Member takes

Implication

Structural mechanism for thrombomodulin identified in vitro; leaves open translation to human antithrombotic strategies.

Structured PICO

Population

In vitro biochemical model of thrombin

Intervention

Active thrombomodulin fragment (TMEGF45)

Comparator

Inactive thrombomodulin fragment (TMEGF56)

Outcome

Changes in the thrombin active site loops measured by amide H/2H exchangesurrogate

Thrombomodulin alters the active site loops of thrombin to shift its substrate specificity toward protein C activation, providing a structural mechanism for its anticoagulant function.

Cite This Study

Koeppe et al. (2005) studied this question.

synapsesocial.com/papers/6a7b33cd4c448619ca0e6bd7 https://doi.org/10.1021/bi0510577

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Thrombomodulin Tightens the Thrombin Active Site Loops To Promote Protein C Activation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Thrombomodulin Tightens the Thrombin Active Site Loops To Promote Protein C Activation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider