January 1, 1998Biochemistry
Thrombomodulin Increases the Rate of Thrombin Inhibition by BPTI
Population
Thrombin and the E192Q mutant
Design
Preclinical
Authors
Discussion
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Member takes
Implication
May refine thrombin regulation models; leaves open in vivo hemostatic effects and clinical translation.
Structured PICO
P
Population
Thrombin and the E192Q mutant
I
Intervention
Thrombomodulin (TM)
O
Outcome
Rate of thrombin inhibition by BPTIsurrogate
Thrombomodulin enhances the initial interaction of thrombin with BPTI, likely involving motion of the 60 loop, resulting in a 10-fold increase in the inhibition rate.
Cite This Study
Rezaie et al. (1998) studied this question.