Why the study?
Does postjunctional alpha 1- and alpha 2-adrenergic antagonism alter myocardial blood flow and coronary resistance in feline hearts with acute regional ischemia?
Population
Anesthetized cats with acute occlusion of the left anterior descending coronary artery and a control group…
Comparison
Postjunctional alpha 1- and alpha 2-adrenergic… vs Control group of anesthetized cats without LAD…
Design
Preclinical
Authors
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Alpha 2 vasoconstriction may preserve function in nonischemic myocardium during ischemia; hypothesis-generating for adrenergic modulation in acute coronary syndromes.
Does postjunctional alpha 1- and alpha 2-adrenergic antagonism alter myocardial blood flow and coronary resistance in feline hearts with acute regional ischemia?
Alpha 2-adrenergic-mediated vasoconstriction is present in well-perfused myocardium but deteriorates during acute regional ischemia, suggesting a role in maintaining global cardiac function.
Westby et al. (1991) studied this question.
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