Why the study?
Does selective alpha 1-adrenergic blockade with doxazosin influence regional myocardial tissue blood flow in anaesthetized cats with acute coronary artery occlusion?
Population
Anaesthetized cats with acute coronary artery occlusion
Comparison
Selective alpha 1-adrenergic blockade with… vs Pre-administration baseline
Design
Preclinical
Authors
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Alpha1-adrenoceptors play a minor role in feline coronary flow regulation; leaves open translation to human acute coronary syndromes.
Does selective alpha 1-adrenergic blockade with doxazosin influence regional myocardial tissue blood flow in anaesthetized cats with acute coronary artery occlusion?
In a feline model of acute coronary occlusion, alpha 1-adrenoceptors play a minor role in regulating coronary blood flow in both normal and ischaemic myocardium.
Westby et al. (1989) studied this question.
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