AU RNA-binding factors differ in their binding specificities and affinities.

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Population

Purified human T cells

Design

Preclinical

Authors

Discussion

May regulate lymphokine mRNA metabolism in T cells; hypothesis-generating for post-transcriptional immune control.

Population

Purified human T cells

Intervention

T cell receptor-mediated stimulation

Outcome

Characterization of binding specificities, affinities, and localization of AU-A, AU-B, and AU-C RNA-binding factors

AU-B and AU-C are structurally related, high-affinity RNA-binding factors that may act as cytoplasmic regulators of lymphokine mRNA metabolism.

Bohjanen et al. (1992) studied this question.

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