February 1, 1991Journal of Biological ChemistryOpen Access

The adenosine-uridine binding factor recognizes the AU-rich elements of cytokine, lymphokine, and oncogene mRNAs.

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Structured PICO

Population

In vitro transcribed mRNAs including granulocyte-macrophage colony-stimulating factor, interferon-gamma, interleukin-3, c-fos, and v-myc, and synthetic RNA transcripts

Intervention

Interaction with adenosine-uridine binding factor (AUBF) and mutations within AUUUA motifs

Comparator

Irrelevant RNA

Outcome

Formation of RNase T1-resistant band-shifted complexessurrogate

AUBF interacts with multiple labile mRNAs containing AUUUA reiterations, suggesting a common mechanism for selective mRNA degradation.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Provides mechanistic insight into mRNA stability; leaves open AUBF's role in cardiovascular gene regulation.

Cite This Study

James S. Malter (1991) studied this question.

synapsesocial.com/papers/6a81f65cde6949a568e04e8d https://doi.org/10.1016/s0021-9258(18)49970-x

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The adenosine-uridine binding factor recognizes the AU-rich elements of cytokine, lymphokine, and oncogene mRNAs.

Structured PICO

Discussion

Implication

Cite This Study

The adenosine-uridine binding factor recognizes the AU-rich elements of cytokine, lymphokine, and oncogene mRNAs.

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider