An A+U-Rich Element RNA-Binding Factor Regulates c- myc mRNA Stability In Vitro

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Population

Human erythroleukemia K562 cells and cell-free mRNA decay systems

Design

Preclinical

Authors

Discussion

Should not yet inform clinical practice; leaves open whether Auf modulates c-myc stability in human disease.

Population

Human erythroleukemia K562 cells and cell-free mRNA decay systems

Intervention

Identification and characterization of cytosolic A+U-rich element RNA-binding factor (Auf)

Outcome

c-myc mRNA degradation activity and RNA-binding capacitysurrogate

The identification of Auf demonstrates that RNA substrate binding and degradation are separable functions in the regulation of c-myc mRNA stability.

Gary Brewer (1991) studied this question.

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