Key result
A cytosolic factor binds to the c-myc A + U-rich element and specifically destabilizes c-myc mRNA in a cell-free system, with RNA binding and degradation appearing to be separable functions.
Population
cell-free mRNA decay system
Comparison
Proteinase K treatment of the cytosolic factor vs Untreated cytosolic factor
Design
Preclinical
Authors
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Separable binding/degradation functions in c-myc mRNA decay extend mechanistic insight; hypothesis-generating and requires cellular/in vivo validation before any clinical consideration.
This basic science study identifies a cytosolic factor that regulates c-myc mRNA stability, demonstrating that RNA substrate binding and degradation are separable functions.
Gary Brewer (1991) studied this question. Cytosolic RNA-binding factor was evaluated on c-myc mRNA stability and degradation. A cytosolic factor binds to the c-myc A + U-rich element and specifically destabilizes c-myc mRNA in a cell-free system, with RNA binding and degradation appearing to be separable functions.
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