Why the study?
Does the immunoglobulin isotype of antimyosin antibodies determine their pathogenicity in inducing autoimmune myocarditis in naive mice?
Population
Naive DBA/2 mice
Comparison
IgG antimyosin antibodies vs IgM antimyosin antibodies
Design
Preclinical
Authors
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Hypothesis-generating for IgG isotype targeting in myocarditis; leaves open human translation from this animal model.
Does the immunoglobulin isotype of antimyosin antibodies determine their pathogenicity in inducing autoimmune myocarditis in naive mice?
Antimyosin antibodies require class switching to the IgG isotype to penetrate cardiac tissue and induce autoimmune myocarditis.
Kuan et al. (2000) studied this question.
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