October 1, 1994Muscle & Nerve
Effects of exercise on muscle activation and metabolism in multiple sclerosis
Why the study?
Does metabolism play a significant role in muscle fatigue during voluntary exercise in patients with mild multiple sclerosis?
Population
14 subjects (6 with mild multiple sclerosis and 8 healthy controls)
Comparison
Intermittent, progressive, isometric… vs Healthy control subjects performing the same…
Design
Case-control
Authors
Discussion
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Implication
Muscle fatigue in mild MS may reflect activation failure rather than metabolic changes; leaves open prospective validation before clinical adoption.
Structured PICO
Does metabolism play a significant role in muscle fatigue during voluntary exercise in patients with mild multiple sclerosis?
P
Population
14 subjects (6 with mild multiple sclerosis and 8 healthy controls)
I
Intervention
Intermittent, progressive, isometric contractions of the ankle dorsiflexors
C
Comparator
Healthy control subjects performing the same exercise
O
Outcome
Maximum voluntary force (MVC), inorganic phosphate (Pi), phosphocreatine (PCr), and pH during exercisesurrogate
Metabolic factors do not play a significant role in the development of muscle fatigue during voluntary exercise in mild MS, suggesting a failure of muscle activation instead.
Cite This Study
Kent‐Braun et al. (1994) studied this question.