Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 1, 1994Muscle & Nerve

Postexercise phosphocreatine resynthesis is slowed in multiple sclerosis

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Is skeletal muscle oxidative metabolism (measured by PCr resynthesis) impaired in multiple sclerosis compared to healthy controls?

Population

13 patients with multiple sclerosis and 8 healthy control subjects

Comparison

Intermittent isometric tetanic contractions of… vs Healthy control subjects performing voluntary…

Design

Case-control

Authors

JKJane A. Kent‐BraunMarquette UniversityKSKhema R. SharmaUniversity of MiamiRMRobert G. MillerUniversidade de Brasília

Discussion

Loading...

Member takes

Implication

Supports impaired skeletal muscle oxidative metabolism in MS; hypothesis-generating for its role in fatigue and need for interventional studies.

Structured PICO

Is skeletal muscle oxidative metabolism (measured by PCr resynthesis) impaired in multiple sclerosis compared to healthy controls?

P
Population
13 patients with multiple sclerosis and 8 healthy control subjects
I
Intervention
Intermittent isometric tetanic contractions of the dorsiflexor muscles elicited by stimulation of the peroneal nerve
C
Comparator
Healthy control subjects performing voluntary isometric exercise of the same muscles
O
Outcome
Rate of intramuscular phosphocreatine (PCr) resynthesis following exercise (half-time T1/2 of PCr recovery)surrogate

Multiple sclerosis is associated with slowed phosphocreatine resynthesis following exercise, indicating impaired oxidative capacity in skeletal muscle.

Cite This Study

Kent‐Braun et al. (1994) studied this question.

synapsesocial.com/papers/6a8d02a6f37eeef560ff1929https://doi.org/10.1002/mus.880170802
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Skeletal Muscle Metabolism in Heart Failure: A 31P Nuclear Magnetic Resonance Spectroscopy Study of Leg Muscle1990 · 45 citations
  2. 2Muscle metabolism in older subjects using <sup>31</sup>P magnetic resonance spectroscopy1991 · 69 citations
  3. 3Electrical stimulation of human muscle studied using 31P‐nuclear magnetic resonance spectroscopy1986 · 23 citations
  4. 4Influence of electrical stimulation on the morphological and metabolic properties of paralyzed muscle1992 · 249 citations
  5. 5Wrist flexor muscles of elite rowers measured with magnetic resonance spectroscopy1989 · 118 citations