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October 1, 1997Annual Review of Physiology

CYTOPLASMIC ATP-DEPENDENT REGULATION OF ION TRANSPORTERS AND CHANNELS: Mechanisms and Messengers

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Population

Ion transporters and channels studied in planar bilayers, excised membrane patches, or with whole-cell patch…

Design

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Authors

DHDonald W. HilgemannElectrophysiology

Discussion

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Overview

Synthesizes ATP-PIP2 mechanisms in cardiac ion transport; extends basic research framework but leaves open clinical translation.

Structured PICO

P
Population
Ion transporters and channels studied in planar bilayers, excised membrane patches, or with whole-cell patch clamp
I
Intervention
Cytoplasmic ATP-dependent regulation mechanisms (protein kinases, lipid kinases, PIP2, allosteric effects, actin cytoskeleton changes)
O
Outcome
Regulation of ion transport and channel activity

Provides a comprehensive overview of the diverse, phosphorylation-dependent and independent mechanisms by which cytoplasmic ATP regulates cellular ion transport.

Cite This Study

Donald W. Hilgemann (1997) studied this question.

synapsesocial.com/papers/6a6f757efebe604dd7086149https://doi.org/10.1146/annurev.physiol.59.1.193
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Nucleotide regulation of ATP sensitive potassium channels1994 · 60 citations
  2. 2Single channel measurements of the calcium release channel from skeletal muscle sarcoplasmic reticulum. Activation by Ca2+ and ATP and modulation by Mg2+.1986 · 410 citations
  3. 3Activation of cardiac ATP-sensitive K+ current during hypoxia: correlation with tissue ATP levels1991 · 93 citations
  4. 4ATP-sensitive potassium channels in physiology, pathophysiology, and pharmacology1992 · 42 citations
  5. 5Regulation of ATP-sensitive K+ channel by membrane-bound protein phosphatases in rat principal tubule cell1995 · 43 citations