Why the study?
Does intracoronary carbachol alter myocardial dynamics and metabolism in the nonworking dog heart?
Population
Electrically paced hearts of dogs subjected to cardiopulmonary bypass
Comparison
Intracoronary infusion of carbamylcholine chloride vs Control, and pretreatment with atropine or…
Design
Preclinical
Authors
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Hypothesis-generating for cholinergic effects on myocardial metabolism in experimental models; leaves open human translation.
Does intracoronary carbachol alter myocardial dynamics and metabolism in the nonworking dog heart?
Cholinergic intervention with carbachol in the nonworking dog heart decreases oxygen metabolism and increases myocardial triglyceride uptake and synthesis, an effect opposite to sympathetic stimulation.
Glaviano et al. (1977) studied this question.
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