The study identifies the complete amino acid sequence of a calcium channel blocker receptor from rabbit lung and demonstrates its functional expression in Xenopus oocytes.
Enables molecular dissection of Ca channel structure-function; leaves open relevance to human disease or CaCB therapy.
The complete amino acid sequence of the receptor for organic calcium channel blockers (CaCB) from rabbit lung has been deduced by cloning and sequence analysis of the cDNA. Synthetic RNA derived from this cDNA induces the formation of a functional CaCB-sensitive high voltage activated calcium channel in Xenopus oocytes.
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Biel et al. (1990) studied this question.
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