Oxidative stress is significantly elevated in patients with cardiac syndrome X and correlates with the severity of exercise-induced ischemia, suggesting a potential role in the disease's pathogenesis.
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Oxidative stress markers associate with CSX severity; hypothesis-generating and should not change practice.
Objectives: To investigate the alterations of oxidative and antioxidative status in patients with cardiac syndrome X (CSX). Materials and methods: Thirty-three patients with CSX (CSX group), 27 patients without CSX (NSX) and 20 healthy volunteers as control group were included into the study. Oxidative status of serum was evaluated by measuring total oxidant status (TOS), lipid hydroperoxide levels (LOOH) and oxidative stress index (OSI) of serum, and antioxidative status of serum was evaluated by measuring total antioxidant capacity (TAC). Also, hsCRP and other biochemical markers were measured in all subjects. Results: The oxidants (TOS, LOOH and OSI) and CRP levels were higher, and TAC was lower in the patients with CSX than NSX group and control group. Also, the oxidants (TOS, LOOH and OSI) and hsCRP levels, a marker of chronic inflammation, were higher, and TAC was lower in the patients with NSX than control group. In addition, in patients with CSX, a significant positive correlation (ß =0.606, p<0.001) was found between the OSI level and ST depression. Conclusion: Oxidants increased and antioxidants decreased, namely oxidative/antioxidative balance shifted to oxidative stress in patients with CSX. Thus, oxidative stress may have a role in the etiopathogenesis of the disease.
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Şahin et al. (2012) studied this question.
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