Temporally Controlled Onset of Dilated Cardiomyopathy Through Disruption of the SRF Gene in Adult Heart
Population
Adult mice with heart-specific tamoxifen-inducible Cre recombinase for SRF disruption
Design
Preclinical
Follow-up
10 weeks
Authors
Discussion
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Member takes
Overview
SRF disruption confirms its essential role in adult mouse cardiac function; provides inducible DCM model but leaves human translation untested.
Structured PICO
P
Population
Adult mice with heart-specific tamoxifen-inducible Cre recombinase for SRF disruption
I
Intervention
Disruption of SRF gene using tamoxifen
O
Outcome
Left ventricular function, contractility, and progression to dilated cardiomyopathysurrogate
SRF is crucial for adult cardiac function, and its disruption in adult mice provides an inducible model for acquired dilated cardiomyopathy.
Cite This Study
Parlakian et al. (2005) studied this question.