Key result
Conditional knockout of serum response factor in the heart-forming region blocked the appearance of rhythmic beating myocytes and attenuated myofibril proteins while up-regulating biomineralization genes.
SRF is essential for nascent sarcomerogenesis and represses the biomineralization gene program in the developing heart via microRNA regulation.
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Does not support clinical change; leaves open SRF-microRNA targeting in human cardiac development.
Niu et al. (2008) studied Cardiac development. Conditional serum response factor (SRF) knockout vs. Control was evaluated on Appearance of rhythmic beating myocytes and gene expression. Conditional knockout of serum response factor in the heart-forming region blocked the appearance of rhythmic beating myocytes and attenuated myofibril proteins while up-regulating biomineralization genes.
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