Population
Mice lacking AT(1A) receptors for ANG II (Agtr1a -/- mice) and wild-type controls
Comparison
Genetic knockout of AT receptor or treatment… vs Wild-type controls
Design
Preclinical
Follow-up
24 hours
Authors
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AT1A receptors are required for urinary concentration in mice; leaves open whether AT1 antagonists alter water handling in patients.
The AT(1A) receptor plays a critical role in maintaining inner medullary structures in the kidney and regulating renal water excretion.
Oliverio et al. (2000) studied this question.
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