What question did this study set out to answer?

To investigate whether tissue levels of alpha-oxoaldehydes, particularly 3-deoxyglucosone (3-DG), mediate hyperglycemia-induced embryonic malformations during early gestation.

December 1, 1998Diabetes

Teratogenicity of 3-deoxyglucosone and diabetic embryopathy.

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Authors

UEUlf J. ErikssonUppsala University PWParri WentzelUppsala University HMHarjit S. MinhasUniversity of Essex

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Implication

In vitro embryonic study demonstrates that 3-deoxyglucosone induces developmental malformations in rat embryos, indicating superoxide-mediated teratogenesis downstream of hyperglycemia.

Key Points

To investigate whether tissue levels of alpha-oxoaldehydes, particularly 3-deoxyglucosone (3-DG), mediate hyperglycemia-induced embryonic malformations during early gestation.
Conducted whole embryo culture using rat embryos exposed in vitro to low glucose (control) or high glucose concentrations.
Cultured control embryos with exogenous 3-DG (100 µmol/l) and assessed the protective effect of superoxide dismutase (SOD) supplementation on dysmorphogenesis and 3-DG tissue concentrations.
High glucose exposure induced severe embryonic dysmorphogenesis and led to a 17-fold increase in embryonic 3-DG concentrations relative to low-glucose controls.
Exogenous 3-DG (100 µmol/l) reproduced both the high tissue 3-DG concentrations and the increased malformation rates observed in high-glucose cultures.
Addition of superoxide dismutase (SOD) decreased malformation rates in embryos exposed to either high glucose or 3-DG, but did not alter embryonic 3-DG concentrations.

Cite This Study

Eriksson et al. (1998) studied this question.

synapsesocial.com/papers/6a6f77c626a7f98052dc20ab https://doi.org/10.2337/diabetes.47.12.1960

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Implication

In vitro embryonic study demonstrates that 3-deoxyglucosone induces developmental malformations in rat embryos, indicating superoxide-mediated teratogenesis downstream of hyperglycemia.

Teratogenicity of 3-deoxyglucosone and diabetic embryopathy.

Discussion

Member takes

Implication

Key Points

Cite This Study

Teratogenicity of 3-deoxyglucosone and diabetic embryopathy.

Discussion

Member takes

Implication

Key Points

Cite This Study

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