Key result
High glucose exposure in chick embryos retarded vascular plexus growth, reduced vasculature density, and induced cardiac hyperplasia, potentially via excess reactive oxygen species production.
Why the study?
Does high glucose exposure impair cardiovascular development in chick embryos?
Population
Chick embryo models (yolk sac membrane and chorioallantoic membrane)
Comparison
High glucose exposure vs Control (normal glucose)
Design
Preclinical
Authors
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High glucose impairs embryonic vasculature in chicks; hypothesis-generating for gestational diabetes mechanisms, no practice change.
Does high glucose exposure impair cardiovascular development in chick embryos?
High glucose exposure impairs angiogenesis and induces cardiac hyperplasia via excess ROS production in developing chick embryos, providing insight into how gestational diabetes may damage embryos.
Jin et al. (2013) studied Cardiovascular dysplasia during early embryo development. High glucose vs. Control was evaluated on Angiogenesis and cardiogenesis. High glucose exposure in chick embryos retarded vascular plexus growth, reduced vasculature density, and induced cardiac hyperplasia, potentially via excess reactive oxygen species production.
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