Why the study?
Does maternal diabetes alter the spinal structure in the brachial enlargement of offspring in a rat model?
Does maternal diabetes alter the spinal structure in the brachial enlargement of offspring in a rat model?
Maternal hyperglycemia in rats causes persistent deleterious morphological changes in the fetal spinal cord, specifically the brachial enlargement, during the postneonatal period.
Alerts to possible spinal risks in offspring of diabetic mothers; leaves open human translation and clinical relevance.
Summary This study was conducted to evaluate the effects o f maternal diabetes on fetal spinal structure, espe cially in brachial enlargement. Sixteen adult female rats were divided into two groups. Diabetes was induced in one group by alloxan agent. Both groups became pregnant by natural matting. On days 7, 14, 21 and 28 after birth, the brachial enlargement of the spinal cord was collected from offspring of all rats and the we ight of neonates was measured. Various histological parameters were determined using histological techniques. The results revealed a significant decrease in transver se spinal diameter and number of neurons of gray matter and an increase in vertical spinal diameter in spinal c ord of offspring of diabetic mothers (ODM) as compared with the control group. The body weight of ODM was significantly more than that of the control group (P<0.05). Maternal hyperglycemia exhibited deleteri ous effects on spinal cord, especially brachial enlargement during fetal life which remained persis tent during postneonatal period.
No takes yet. Share an insight, caveat, or question.
Khaksar et al. (2010) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: