Why the study?
Does pregnancy induce resistance to activated protein C in healthy women?
Population
20 healthy pregnant women
Comparison
Pregnancy vs Baseline measurements taken at > 8 weeks…
Design
Cohort
Follow-up
> 8 weeks post-partum
Authors
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APC resistance develops progressively in healthy pregnancy; leaves open its contribution to gestational VTE and need for prospective validation.
Does pregnancy induce resistance to activated protein C in healthy women?
Pregnancy induces a progressive resistance to activated protein C, which may contribute to the increased risk of venous thrombosis during gestation.
Cumming et al. (1995) studied this question.
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