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June 28, 2011EP EuropaceOpen Access

Regional fractionation and dominant frequency in persistent atrial fibrillation: effects of left atrial ablation and evidence of spatial relationship

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Why the study?

Does left atrial ablation alter regional fractionation and dominant frequency in patients with persistent atrial fibrillation?

Population

23 patients with persistent atrial fibrillation undergoing catheter ablation using three-dimensional…

Comparison

Circumferential pulmonary vein and left atrial… vs Pre-ablation baseline (intra-patient comparison)

Design

Cohort

Authors

JTJiun TuanMJMohamed JeilanSKSuman Kundu

Discussion

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Overview

Ablation was associated with reduced fractionation and dominant frequency; hypothesis-generating for their role as ablation endpoints in persistent AF.

Structured PICO

Does left atrial ablation alter regional fractionation and dominant frequency in patients with persistent atrial fibrillation?

P
Population
23 patients with persistent atrial fibrillation undergoing catheter ablation using three-dimensional navigation
I
Intervention
Circumferential pulmonary vein and left atrial roof ablation
C
Comparator
Pre-ablation baseline (intra-patient comparison)
O
Outcome
Changes in regional fractionation (CFE-mean), dominant frequency (DF), and organization index (OI) before and after ablationsurrogate

Left atrial ablation in persistent AF reduces global dominant frequency and decreases the degree of fractionation, though the two parameters share only modest spatial correlation and are affected differently by ablation.

Cite This Study

Tuan et al. (2011) studied this question.

synapsesocial.com/papers/6a6f79463ce530166bc2a176https://doi.org/10.1093/europace/eur174
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Simultaneous Biatrial Computerized Mapping During Permanent Atrial Fibrillation in Patients with Organic Heart Disease2002 · 125 citations
  2. 2Development and Validation of an ECG Algorithm for Identifying Accessory Pathway Ablation Site in Wolff‐Parkinson‐White Syndrome1998 · 425 citations
  3. 3High‐Density Mapping of Atrial Fibrillation in Humans: Relationship Between High‐Frequency Activation and Electrogram Fractionation2008 · 77 citations
  4. 4Spatiotemporal Organization of the Left Atrial Substrate After Circumferential Pulmonary Vein Isolation of Atrial Fibrillation2009 · 91 citations
  5. 5Spatially Distributed Dominant Excitation Frequencies Reveal Hidden Organization in Atrial Fibrillation in the Langendorff‐Perfused Sheep Heart2000 · 182 citations