New fecal test for non-invasive Helicobacter pylori detection: A diagnostic accuracy study

AIM: C-urea breath test as the reference standard, and explore bacterial antibiotic resistance. METHODS: infection. We also used the index diagnostic test to examine mutations conferring resistance to clarithromycin and levofloxacin. Independent investigators analyzed index test and reference test standard results blinded to the other test findings. We estimated sensitivity, specificity, positive (PPV) and negative (NPV) predictive value, diagnostic accuracy, positive and negative likelihood ratio (LR), together with 95% confidence intervals (CI). RESULTS: infection. Of these, 27 (32.5%) had bacterial strains resistant to clarithromycin, 3 (3.6%) to levofloxacin, and 4 (4.8%) to both antibiotics. CONCLUSION: infection while additionally enabling the assessment of bacterial antibiotic resistances.