Population
Human cardiac Na(+) channels expressed in human embryonic kidney (HEK) 293 cells
Design
Preclinical
Authors
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Animal data preclude changes in antiarrhythmic selection; leaves open pKa relevance for human Na+ channel block.
The difference in the degree of ionization (pKa) between lidocaine and flecainide dictates their distinct mechanisms of cardiac Na+ channel blockade, despite sharing a common receptor.
Liu et al. (2003) studied this question.
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