I₂‐DMSO‐Mediated Cascade Cyclization of β‐Ketosulfoxonium Ylides and β‐Enaminones: Synthesis of Quaternary‐Carbon‐Centered 2‐Hydroxy‐pyrrol‐3(2H)‐ones

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A novel I 2 ‐DMSO‐mediated cascade cyclization approach for synthesizing 2‐hydroxy‐pyrrol‐3(2 H )‐one scaffold from readily accessible β ‐ketosulfoxonium ylides and β ‐enaminone derivatives has been developed. Under metal‐free and mild conditions, this cascade transformation facilitates the formation of one C−C bond and one C−N bond in a single reaction vessel, exhibiting a wide range of functional group compatibility. In addition, this method added an active hydroxyl group to a quaternary carbon center.