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July 1, 1986Journal of Clinical InvestigationOpen Access

Biochemical selectivity of oral versus intravenous aspirin in rats. Inhibition by oral aspirin of cyclooxygenase activity in platelets and presystemic but not systemic vessels.

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Authors

CCChiara CerlettiGeneral / Preventive / Lipids MGMaria Concetta GambinoMario Negri Institute for Pharmacological Research SGSilvio GarattiniOspedale Santa Maria della Misericordia di Udine

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Implication

Aspirin route affects platelet versus vascular COX selectivity in rats; hypothesis-generating and should not yet inform clinical practice.

Key Points

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Cite This Study

Cerletti et al. (1986) studied this question.

synapsesocial.com/papers/6a6f80dd87f9210571272b80 https://doi.org/10.1172/jci112569

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Inhibition of platelet prostaglandin synthetase by oral aspirin.1978 · 557 citations
2Dose-Related Kinetics of Aspirin1984 · 558 citations
3Pharmacology of platelet inhibition in humans: implications of the salicylate-aspirin interaction.1985 · 103 citations
4Salicylate-aspirin interaction in the rat. Evidence that salicylate accumulating during aspirin administration may protect vascular prostacyclin from aspirin-induced inhibition.1981 · 58 citations
5Differential Inhibition by Aspirin of Vascular and Platelet Prostaglandin Synthesis in Atherosclerotic Patients1983 · 448 citations