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Oxidative stress is involved in the development and progression of diabetic complications. Salvia fruticosa was reported to have a protective action against oxidative stress. In the present study, diabetes was induced in male Wister rats using streptozotocin (60 mg/ kg body weight). Diabetic rats exhibit not only the symptoms of diabetes like the loss of body weight, hyperglycemia, polyuria and polydipsia but oxidative stress. Daily ingestion of 1gm/kg of body weight of Salvia fruticosa extract for 60 days to diabetic rats reversed the adverse effect of diabetes on rats. Salvia fruticose extract provides better control of glucose levels and body weight loss. In heart, kidney, and liver, diabetes-induced changes in lipid peroxidation marker (malondialdehyde) were entirely attenuated by Salvia fruticose treatment. This was accompanied by a significant decrease in reduced glutathione and superoxide dismutase activity and increase in catalase activity in these tissues. Results from this study indicate that Salvia fruticosa extract modulates the adverse effect of diabetes on streptozotocin-induced diabetic rats. SF extract was evaluated for in vitro antioxidant capacity by estimating of total phenolics content, the ferric reducing antioxidant power (FRAP) assay, 1,1-diphenyl-2-picryhydrazyl (DPPH), and ABTS assays. The extract was found to inhibit aglucosidase activity similar to acarbose. Salvia fruticosa extract may have a potential therapeutic effect due to its antioxidant and anti-hyperglycemic properties
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Hamza et al. (2016) studied this question.
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