Why the study?
Does additional intensification treatment increase treatment-related mortality in children with acute lymphoblastic leukaemia?
Population
1612 children with childhood acute lymphoblastic leukaemia (ALL) in the UK
Comparison
Intensive induction therapy, central nervous… vs No additional intensification treatment
Design
RCT, Randomisation to receive blocks of additional intensification treatment…
Follow-up
5 years
Authors
Loading...
Intensification blocks merit standard use in pediatric ALL; confirms survival gains without excess remission deaths excluding transplant recipients.
Does additional intensification treatment increase treatment-related mortality in children with acute lymphoblastic leukaemia?
In children with ALL, intensification treatment improved 5-year disease-free survival by 14% without significantly increasing the risk of remission death when bone marrow transplant patients were excluded.
Wheeler et al. (1996) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: