Adiposity of the Heart

Letters3 October 2006Adiposity of the HeartLidia S. Szczepaniak, PhD, Jonathan M. McGavock, PhD, Ronald G. Victor, MD, and Roger H. Unger, MDLidia S. Szczepaniak, PhDFrom University of Texas Southwestern Medical Center, Dallas, TX 75390-8899.Search for more papers by this author, Jonathan M. McGavock, PhDFrom University of Texas Southwestern Medical Center, Dallas, TX 75390-8899.Search for more papers by this author, Ronald G. Victor, MDFrom University of Texas Southwestern Medical Center, Dallas, TX 75390-8899.Search for more papers by this author, and Roger H. Unger, MDFrom University of Texas Southwestern Medical Center, Dallas, TX 75390-8899.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-145-7-200610030-00022 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE: Dr. Kanna's suggestion of a relationship between lipid overload of cardiomyocytes and abnormal cardiac late potentials may provide a valuable new dimension in evaluation of the obese heart. It will be of interest to learn whether measures that reverse cardiac steatosis overturn the abnormal late potentials. The role of elevated free fatty acids in the development of cardiac arrhythmias has been explored by others (1–3); this may be a primary cause of abnormal late potentials in individuals with type 2 diabetes or the metabolic syndrome.Dr. Leslie points out that Austin Flint described fatty heart disease almost 150 ...References1. Manzella D, Grella R, Marfella R, Giugliano D, Paolisso G. Elevated post-prandial free fatty acids are associated with cardiac sympathetic overactivity in Type II diabetic patients [Letter]. Diabetologia. 2002;45:1737-8. [PMID: 12552366] CrossrefMedlineGoogle Scholar2. Manzella D, Barbieri M, Rizzo MR, Ragno E, Passariello N, Gambardella A, et al. Role of free fatty acids on cardiac autonomic nervous system in noninsulin-dependent diabetic patients: effects of metabolic control. J Clin Endocrinol Metab. 2001;86:2769-74. [PMID: 11397885] CrossrefMedlineGoogle Scholar3. Paolisso G, Gualdiero P, Manzella D, Rizzo MR, Tagliamonte MR, Gambardella A, et al. Association of fasting plasma free fatty acid concentration and frequency of ventricular premature complexes in nonischemic non–insulin-dependent diabetic patients. Am J Cardiol. 1997;80:932-7. [PMID: 9382011] CrossrefMedlineGoogle Scholar4. Chiu HC, Kovacs A, Ford DA, Hsu FF, Garcia R, Herrero P, et al. A novel mouse model of lipotoxic cardiomyopathy. J Clin Invest. 2001;107:813-22. [PMID: 11285300] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: Lidia S. Szczepaniak, PhD; Jonathan M. McGavock, PhD; Ronald G. Victor, MD; Roger H. Unger, MDAffiliations: From University of Texas Southwestern Medical Center, Dallas, TX 75390-8899.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAdiposity of the Heart Gianluca Iacobellis and Arya M. Sharma Adiposity of the Heart Balavenkatesh Kanna Adiposity of the Heart Bruce R. Leslie Adiposity of the Heart Michael J. Zema Metrics Cited byDeletion of protein kinase B2 preserves cardiac function by blocking interleukin-6-mediated injury and restores blood pressure during angiotensin II/high-salt-diet-induced hypertension 3 October 2006Volume 145, Issue 7 Page: 555 Keywords Cardiomyocytes Enzymes Fats Fatty acids Heart Ligases Myocardium Obesity Steatosis Type 2 diabetes ePublished: 3 October 2006 Issue Published: 3 October 2006 Copyright & PermissionsCopyright © 2006 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...