Adiposity of the Heart

Letters3 October 2006Adiposity of the HeartGianluca Iacobellis, MD, PhD and Arya M. Sharma, MD, PhDGianluca Iacobellis, MD, PhDFrom McMaster University, Hamilton General Hospital, Hamilton, Ontario L8L 2X2, Canada. and Arya M. Sharma, MD, PhDFrom McMaster University, Hamilton General Hospital, Hamilton, Ontario L8L 2X2, Canada.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-145-7-200610030-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR: We read the review by McGavock and colleagues (1) with great interest. The concept of a relationship of myocardial lipid content with generalized adiposity and potentially with cardiac morphologic characteristics and function in obese patients is intriguing. We also agree that intramyocardial fat content detected by magnetic resonance spectroscopy could be a target for drugs that interact with the adipose tissue. Nevertheless, we would like to point out the relationship of the adiposity around the heart with visceral adiposity and cardiac structure in humans.There is now compelling evidence that the epicardial fat tissue, the visceral fat ...References1. McGavock JM, Victor RG, Unger RH, Szczepaniak LS. Adiposity of the heart, revisited. Ann Intern Med. 2006;144:517-24. [PMID: 16585666] LinkGoogle Scholar2. Iacobellis G, Corradi D, Sharma AM. Epicardial adipose tissue: anatomic, biomolecular and clinical relationships with the heart. Nat Clin Pract Cardiovasc Med. 2005;2:536-43. [PMID: 16186852] CrossrefMedlineGoogle Scholar3. Iacobellis G, Pistilli D, Gucciardo M, Leonetti F, Miraldi F, Brancaccio G, et al. Adiponectin expression in human epicardial adipose tissue in vivo is lower in patients with coronary artery disease. Cytokine. 2005;29:251-5. [PMID: 15749025] MedlineGoogle Scholar4. Iacobellis G, Assael F, Ribaudo MC, Zappaterreno A, Alessi G, Di Mario U, et al. Epicardial fat from echocardiography: a new method for visceral adipose tissue prediction. Obes Res. 2003;11:304-10. [PMID: 12582228] CrossrefMedlineGoogle Scholar5. Iacobellis G, Ribaudo MC, Assael F, Vecci E, Tiberti C, Zappaterreno A, et al. Echocardiographic epicardial adipose tissue is related to anthropometric and clinical parameters of metabolic syndrome: a new indicator of cardiovascular risk. J Clin Endocrinol Metab. 2003;88:5163-8. [PMID: 14602744] CrossrefMedlineGoogle Scholar6. Iacobellis G, Leonetti F. Epicardial adipose tissue and insulin resistance in obese subjects. J Clin Endocrinol Metab. 2005;90:6300-2. [PMID: 16091479] CrossrefMedlineGoogle Scholar7. Iacobellis G, Ribaudo MC, Zappaterreno A, Iannucci CV, Leonetti F. Relation between epicardial adipose tissue and left ventricular mass. Am J Cardiol. 2004;94:1084-7. [PMID: 15476634] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From McMaster University, Hamilton General Hospital, Hamilton, Ontario L8L 2X2, Canada.Disclosures: None disclosed. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoAdiposity of the Heart*, Revisited Jonathan M. McGavock , Ronald G. Victor , Roger H. Unger , and Lidia S. Szczepaniak Adiposity of the Heart Lidia S. Szczepaniak , Jonathan M. McGavock , Ronald G. Victor , and Roger H. Unger Adiposity of the Heart Michael J. Zema Adiposity of the Heart Balavenkatesh Kanna Adiposity of the Heart Bruce R. Leslie Metrics Cited ByRelation of epicardial fat thickness and brachial flow-mediated vasodilation with coronary artery diseaseEffects of Statins on the Epicardial Fat Thickness in Patients with Coronary Artery Stenosis Underwent Percutaneous Coronary Intervention: Comparison of Atorvastatin with Simvastatin/EzetimibeEchocardiographic Epicardial Fat: A Review of Research and Clinical ApplicationsEchocardiographic epicardial fat: A new tool in the white coat pocketAbdominal obesity and the metabolic syndrome: A surgeon's perspectiveSubstantial Changes in Epicardial Fat Thickness After Weight Loss in Severely Obese SubjectsHuman epicardial adipose tissue: A review 3 October 2006Volume 145, Issue 7Page: 554-555KeywordsAdipose tissueBloodFatsHeartMagnetic resonance imagingMagnetic resonance spectroscopyMetabolic syndromeMyocardiumOverweightSkeletal muscles ePublished: 3 October 2006 Issue Published: 3 October 2006 CopyrightCopyright © 2006 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...