Why the study?
Pathophysiological mechanisms and long-term consequences of sepsis-induced myocardial injury in septic shock remain poorly understood.
Myocardial edema is proposed as a potentially relevant and largely unexplored mechanism of human septic cardiomyopathy associated with tissue injury and remodeling.
Myocardial edema may link to injury in septic shock; hypothesis-generating and requires prospective validation before practice change.
Septic cardiomyopathy is an increasingly relevant topic in clinical management of septic shock. However, pathophysiological mechanisms and long-term consequences of sepsis-induced myocardial injury are still poorly understood. Herein, new clinical and histological evidence is provided suggesting an association of myocardial edema formation with tissue injury and subsequent remodeling in septic shock patients. This preliminary data supports myocardial edema as a potentially relevant and largely unexplored mechanism of human septic cardiomyopathy.
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Vasques‐Nóvoa et al. (2019) studied this question.
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