Population
Tpm3.1-overexpressing mice, Tpm3.1-null mice, and 3T3-L1 adipocytes
Comparison
Genetic manipulation or inhibition of Tpm3.1 vs Wild-type or control models (implied)
Design
Preclinical
Authors
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Tpm3.1 modulation of glucose uptake merits target validation studies; leaves open translation to human insulin resistance or cardiovascular risk.
Tpm3.1 regulates insulin-stimulated glucose uptake by determining the balance of actin filament populations involved in GLUT4 vesicle trafficking.
Kee et al. (2015) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: