Answers are grounded in this paper and cite their sources.
Blood and lymph vessel growth is regulated by Tie-2 and the VEGFR-3 receptor tyrosine kinases. These proteins also play major roles in the growth and metastasis of cancers. A novel class of inhibitors of these signal-transducing proteins, and of the IGF1R kinase (such as 1), is identified from a natural product derived compound library. This discovery opens up new opportunities for the development of antitumor agents.
No takes yet. Share an insight, caveat, or question.
Stahl et al. (2002) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: