Why the study?
Yangxin Tongluo decoction is clinically used for sepsis-induced cardiac dysfunction, but its therapeutic effects and underlying mechanisms remain unclear.
Does Yangxin Tongluo decoction (YXTLD) improve cardiac dysfunction and alleviate inflammation and oxidative stress in LPS-induced sepsis models?
Does Yangxin Tongluo decoction (YXTLD) improve cardiac dysfunction and alleviate inflammation and oxidative stress in LPS-induced sepsis models?
Yangxin Tongluo decoction protects against sepsis-induced cardiac dysfunction in preclinical models by attenuating inflammation, oxidative stress, and apoptosis via Nrf2 pathway activation.
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YXTLD may attenuate sepsis cardiac dysfunction via Nrf2; leaves open clinical efficacy in humans.
Yang et al. (2026) studied this question.
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