Key result
Xijiao Dihuang decoction improved cardiac function and attenuated inflammation and apoptosis in a murine sepsis model via suppressing TLR4/NF-κB and activating PI3K/AKT pathways.
Why the study?
Xijiao Dihuang decoction is widely used to treat sepsis, but the mechanisms underlying its effects on cardiac dysfunction remain incompletely elucidated.
Does Xijiao Dihuang decoction improve cardiac function and reduce inflammation in a murine model of sepsis?
Does Xijiao Dihuang decoction improve cardiac function and reduce inflammation in a murine model of sepsis?
XJDHT protects against sepsis-induced cardiac dysfunction in mice by modulating the TLR4/NF-κB and PI3K/AKT pathways.
Authors
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Hypothesis-generating for XJDHT in sepsis cardiomyopathy; prospective human trials needed before clinical consideration.
Li et al. (2024) studied Sepsis-induced cardiac dysfunction. Xijiao Dihuang decoction (XJDHT) vs. Saline solution was evaluated on Myocardial function, pathological change, and inflammation. Xijiao Dihuang decoction improved cardiac function and attenuated inflammation and apoptosis in a murine sepsis model via suppressing TLR4/NF-κB and activating PI3K/AKT pathways.
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