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July 1, 1970The Journal of PhysiologyOpen Access

The effect of the tetraethylammonium ion on the delayed currents of frog skeletal muscle

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Population

Frog skeletal muscle fibres

Design

Preclinical

Authors

PSPeter StanfieldGoogle (United States)

Discussion

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Implication

Animal data on K+ conductance in frog muscle warrant caution before human application; leaves open relevance to cardiac electrophysiology.

Structured PICO

P
Population
Frog skeletal muscle fibres
I
Intervention
Tetraethylammonium (TEA) ion (e.g., 58 mM)
O
Outcome
Delayed outward potassium current and maximum potassium conductance (g(K))surrogate

TEA significantly reduces maximum potassium conductance and slows the onset of delayed potassium currents in frog skeletal muscle, with differential effects on fast and slow phases suggesting different potassium channels.

Cite This Study

Peter Stanfield (1970) studied this question.

synapsesocial.com/papers/6a6f86398031ec7bb1dbcd05https://doi.org/10.1113/jphysiol.1970.sp009163
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Actions of some anions on electrical properties and mechanical threshold of frog twitch muscle1968 · 63 citations
  2. 2The relation of membrane changes to contraction in twitch muscle fibres1969 · 97 citations