Multiple blocking mechanisms of ATP‐sensitive potassium channels of frog skeletal muscle by tetraethylammonium ions.

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Population

Sarcolemmal vesicles from frog skeletal muscle (ATP-sensitive K+ channels)

Design

Preclinical

Authors

Discussion

Frog skeletal muscle data offer no clinical guidance; leaves open multi-site TEA+ block in mammalian KATP channels.

Population

Sarcolemmal vesicles from frog skeletal muscle (ATP-sensitive K+ channels)

Intervention

Tetraethylammonium ions (TEA+) and other quaternary ammonium ions (TMA+, TPA+) applied to the external or internal surface of the membrane patch

Outcome

Channel blocking mechanisms, including kinetics, affinities (Kd), and voltage dependencesurrogate

TEA+ blocks ATP-sensitive K+ channels in frog skeletal muscle via three distinct binding sites with different kinetics and voltage dependencies.

Davies et al. (1989) studied this question.

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