January 1, 2008Journal of Cardiovascular Magnetic ResonanceOpen Access

Relation between myocardial edema and myocardial mass during the acute and convalescent phase of myocarditis – a CMR study

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Why the study?

Is the resolution of myocardial edema associated with a decrease in myocardial mass during the convalescent phase of acute myocarditis?

Population

21 patients with acute myocarditis confirmed by CMR (mean age 36.4 years, 76% male) and 11 healthy volunteers.

Design

Cohort, Image analysis was done by one investigator blinded to the patients'…

Follow-up

1 year

Authors

AZAnja ZagrosekCardiac Imaging RWRalf WaßmuthHochschule Osnabrück HAHassan Abdel‐AtyRoyal Marsden NHS Foundation Trust

Discussion

Member takes

Implication

Transient LV mass increase resolves with edema in myocarditis; supports CMR phenotyping but leaves open prognostic utility.

Structured PICO

Is the resolution of myocardial edema associated with a decrease in myocardial mass during the convalescent phase of acute myocarditis?

Population

21 patients with acute myocarditis confirmed by CMR (mean age 36.4 years, 76% male) and 11 healthy volunteers.

Outcome

Change in left ventricular (LV) mass and myocardial edema (T2 ratio) from the acute phase to the convalescent phase (1 year later).surrogate

Reversible myocardial edema in acute myocarditis is associated with a transient increase in left ventricular mass that normalizes during the convalescent phase.

Limitations

Lack of endomyocardial biopsies
Small sample size
Not a fully prospective study
Possible effect of medication on findings cannot be fully ascertained

Cite This Study

Zagrosek et al. (2008) studied this question.

synapsesocial.com/papers/6a6f87d5f44fa9f079dcfb5e https://doi.org/10.1186/1532-429x-10-19

Topics

Myocarditis

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