Why the study?
Heart failure and arrhythmia frequently coexist in adults with congenital heart disease, but have traditionally been managed in distinct clinical silos despite mechanistic, therapeutic, and prognostic overlap.
Highlights the critical intersection of heart failure and arrhythmia in adults with congenital heart disease, advocating for a multidisciplinary management approach.
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Supports integrated HF-arrhythmia care in ACHD; extends mechanistic overlap for targeted trials.
Together, heart failure and arrhythmia represent the most important cardiovascular sources of morbidity and mortality among adults with congenital heart disease (ACHDs). Although traditionally conceptualized as operating within 2 distinct clinical silos, these scenarios frequently coexist within the same individual; consequently the mechanistic, therapeutic, and prognostic overlap between them demands increased recognition. In fact, given the near ubiquity of heart failure and arrhythmia among ACHDs, there is perhaps no other arena within cardiology where this critical intersection is more frequently observed. Optimal care for ACHDs therefore requires a heightened awareness of the relevant interactions as well as the pharmacologic and interventional resources that are increasingly available to the treating cardiologist. This review explores and highlights the overlap between these 2 fields to recommend a parallel, yet interactive, multidisciplinary approach to clinical management. Congenital heart disease categories are broken down into their archetypal subtypes to highlight subtleties of the pathophysiology, evaluation, and therapeutic approach.
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Moore et al. (2022) studied this question.
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