January 22, 2014Theoretical Biology and Medical ModellingOpen Access

A model to determine the effect of collagen fiber alignment on heart function post myocardial infarction

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Why the study?

Does collagen fiber alignment and density affect left ventricular function post-myocardial infarction in a mathematical model?

Population

A four-region, multi-scale, cylindrical mathematical model of the post-myocardial infarction left ventricle

Comparison

Parametric variation of collagen structure and… vs Baseline healthy left ventricle and varying…

Design

Preclinical

Authors

AVAndrew VoorheesJohnson & Johnson (United States)HHHai‐Chao HanHeart Failure & Transplant

Discussion

Member takes

Implication

Hypothesis-generating for longitudinal collagen alignment post-MI; leaves open translation to human scar modulation therapies.

Structured PICO

Does collagen fiber alignment and density affect left ventricular function post-myocardial infarction in a mathematical model?

Population

A four-region, multi-scale, cylindrical mathematical model of the post-myocardial infarction left ventricle

Intervention

Parametric variation of collagen structure and organization (collagen orientation, angular dispersion, fiber stiffness, crimp angle, and density)

Comparator

Baseline (pre-MI) healthy left ventricle and varying parametric states

Outcome

Left ventricular function (stroke volume and ejection fraction)surrogate

A mathematical model demonstrates that longitudinal alignment of collagen fibers in post-MI scar tissue maximizes left ventricular function by increasing circumferential compliance and improving diastolic filling.

Limitations

Assumes a thin-walled geometry which ignores the effects of transmural variation in stresses
Models the infarct as a single layer with a disperse fiber alignment rather than multiple layers
Neglects the effects of ventricular torsion
Assumption that adjacent regions share deformations along shared edges leads to a non-continuous stress field
Ignores other structural proteins such as elastin and ECM modifications such as cross-linking

Cite This Study

Voorhees et al. (2014) studied this question.

synapsesocial.com/papers/6a6f8b0af44fa9f079dcfe18 https://doi.org/10.1186/1742-4682-11-6

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A model to determine the effect of collagen fiber alignment on heart function post myocardial infarction

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

A model to determine the effect of collagen fiber alignment on heart function post myocardial infarction

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

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Also Consider