Extracellular matrix remodeling following myocardial injury
Key result
Matrix metalloproteinase inhibition and targeted deletion have beneficial effects post-myocardial infarction by targeting the extracellular matrix to prevent adverse left ventricular remodeling.
Why the study?
Does matrix metalloproteinase (MMP) inhibition prevent adverse left ventricular remodeling following myocardial infarction?
Population
Myocardial infarction (MI) with subsequent left ventricular (LV) remodeling
Design
Review
Authors
Discussion
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Member takes
Implication
MMP inhibition may limit post-MI remodeling; leaves open confirmation of clinical benefit in trials.
Key Points
- To outline the molecular mechanisms of extracellular matrix remodeling and evaluate the regulatory role of matrix metalloproteinases in adverse left ventricular dilation following myocardial infarction.
- Reviewed cellular and molecular pathways of cardiac extracellular matrix turnover, scar formation, and cell-surface integrin signaling following ischemic myocardial injury.
- Synthesized findings from targeted gene deletion and pharmacological inhibition studies evaluating matrix metalloproteinases in post-infarction left ventricular remodeling.
- Extracellular matrix degradation and replacement collagen deposition in the infarct zone are coordinated by matrix metalloproteinases and integrins to form mature scar tissue.
- Unchecked matrix metalloproteinase activity actively drives adverse left ventricular dilation, whereas selective inhibition or genetic ablation of these enzymes attenuates progressive ventricular dysfunction.
Structured PICO
Does matrix metalloproteinase (MMP) inhibition prevent adverse left ventricular remodeling following myocardial infarction?
P
Population
Myocardial infarction (MI) with subsequent left ventricular (LV) remodeling
I
Intervention
Matrix metalloproteinase (MMP) inhibition or targeted deletion
O
Outcome
Left ventricular (LV) remodeling and dilation
This review highlights the role of matrix metalloproteinases in extracellular matrix remodeling post-MI and suggests MMP inhibition as a potential therapeutic strategy to prevent adverse LV remodeling.
Cite This Study
Lindsey et al. (2003) conducted a review in Myocardial infarction and left ventricular remodeling. Matrix metalloproteinase (MMP) inhibition was evaluated. Matrix metalloproteinase inhibition and targeted deletion have beneficial effects post-myocardial infarction by targeting the extracellular matrix to prevent adverse left ventricular remodeling.