Key result
The cardiac extracellular matrix undergoes dynamic changes following myocardial injury, playing a critical role in regulating inflammation, repair, and remodeling.
Understanding the dynamic changes in the cardiac extracellular matrix during injury and repair may guide the development of novel matrix-based therapies to attenuate adverse remodeling and promote regeneration.
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May support matrix-targeted therapies to limit post-injury remodeling; leaves open clinical efficacy pending prospective trials.
Nikolaos G. Frangogiannis (2017) conducted a review in Myocardial injury, repair, and remodeling. The cardiac extracellular matrix undergoes dynamic changes following myocardial injury, playing a critical role in regulating inflammation, repair, and remodeling.
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