Key result
This review summarizes current knowledge on the processes involved in extracellular matrix remodeling after myocardial infarction and identifies gaps that still need to be filled.
Why the study?
The extracellular matrix is intricately involved in all stages of wound healing after MI, prompting a synthesis of current knowledge and identification of remaining knowledge gaps.
This review summarizes current knowledge and identifies gaps regarding extracellular matrix remodeling processes after myocardial infarction.
Highlights unresolved post-MI ECM remodeling processes; leaves open targeted mechanistic studies before clinical translation.
Myocardial Infarction (MI) initiates a series of wound healing events that begins with up-regulation of an inflammatory response and culminates in scar formation. The extracellular matrix (ECM) is intricately involved in all stages from initial break down of existing ECM to synthesis of new ECM to form the scar. This review will summarize our current knowledge on the processes involved in ECM remodeling after MI and identify the gaps that still need to be filled.
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Tenkorang et al. (2019) conducted a review in Myocardial Infarction. This review summarizes current knowledge on the processes involved in extracellular matrix remodeling after myocardial infarction and identifies gaps that still need to be filled.
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