Why the study?
Does the interaction of Helicobacter pylori infection and NSAID use affect the risk of bleeding peptic ulcers?
Population
520 subjects total: 185 consecutive patients with bleeding peptic ulcers and 185 hospitalized matched…
Comparison
Helicobacter pylori infection and NSAID use vs Absence of Helicobacter pylori infection and/or…
Design
Case-control
Authors
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Should not yet change NSAID or H. pylori strategies; leaves open confirmation of gastric-specific interaction.
Does the interaction of Helicobacter pylori infection and NSAID use affect the risk of bleeding peptic ulcers?
The interaction of H. pylori infection and NSAID use appears to decrease the risk of bleeding from gastric ulcers, but not duodenal ulcers.
Santolaria et al. (1999) studied this question.
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