Key result
NSAID usage and advanced age (≥65 years) increased the risk of bleeding gastric ulcer (OR 6.8 and 3.4, respectively), with H. pylori further increasing risk (OR 2.4) when both are present.
Why the study?
Do NSAID usage and Helicobacter pylori infection interact to increase the risk of bleeding in patients with gastric ulcer?
Observational (n=217)
Do NSAID usage and Helicobacter pylori infection interact to increase the risk of bleeding in patients with gastric ulcer?
Odds Ratio: 6.8
NSAID usage and advanced age are independent risk factors for bleeding gastric ulcer, and H. pylori infection further increases this risk when these factors are present.
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May inform bleeding risk stratification in NSAID users ≥65; hypothesis-generating for H. pylori interaction, needs prospective confirmation.
Ng et al. (2000) conducted an observational in Gastric ulcer (n=217). NSAID usage vs. No NSAID usage was evaluated on Bleeding gastric ulcer (OR 6.8). NSAID usage and advanced age (≥65 years) increased the risk of bleeding gastric ulcer (OR 6.8 and 3.4, respectively), with H. pylori further increasing risk (OR 2.4) when both are present.
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