June 12, 2007Journal of Biological ChemistryOpen Access

Angiopoietin-1 Requires p190 RhoGAP to Protect against Vascular Leakage in Vivo

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Why the study?

Does Angiopoietin-1 require p190 RhoGAP to prevent endotoxin-induced vascular leakage in mice?

Population

Mice with endotoxemia-induced pulmonary vascular leak and inflammation, and endothelial cell models

Comparison

Angiopoietin-1 treatment with or without p190… vs Endotoxin alone (implied control conditions)

Design

Preclinical

Authors

TMTadanori MammotoMedical College of Wisconsin SPSamir M. ParikhThe University of Texas Southwestern Medical Center AMAkiko MammotoMedical College of Wisconsin

Discussion

Member takes

Implication

p190 RhoGAP mediates Ang-1 protection in murine endotoxemia; leaves open translation to human sepsis therapies.

Structured PICO

Does Angiopoietin-1 require p190 RhoGAP to prevent endotoxin-induced vascular leakage in mice?

Population

Mice with endotoxemia-induced pulmonary vascular leak and inflammation, and endothelial cell models

Intervention

Angiopoietin-1 (Ang-1) treatment with or without p190 RhoGAP small interfering RNA

Comparator

Endotoxin alone (implied control conditions)

Outcome

Vascular permeability, cytoskeletal organization, and pulmonary vascular leak and inflammationsurrogate

Angiopoietin-1 protects against endotoxin-induced vascular leakage by regulating the endothelial cytoskeleton via p190 RhoGAP-mediated coordination of Rac1 and RhoA.

Cite This Study

Mammoto et al. (2007) studied this question.

synapsesocial.com/papers/6a6f8e43f44fa9f079dd0163 https://doi.org/10.1074/jbc.m702169200

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Angiopoietin-1 Requires p190 RhoGAP to Protect against Vascular Leakage in Vivo

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Angiopoietin-1 Requires p190 RhoGAP to Protect against Vascular Leakage in Vivo

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider