January 1, 2000Pathophysiology of Haemostasis and Thrombosis

Mathematical Derivative Applied to International Normalised Ratio and Analytical Variations in Oral Anticoagulant Therapy Control

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Population

Plasma samples (87 PT ratio measurements)

Comparison

Mathematical derivative application to INR… vs Expected values after 1:2 dilution; other systems

Authors

GIGiovanni IntrocasoClinical Research Management ACA. Cuboni ARA. RattoCentro Cardiologico Monzino

Discussion

Member takes

Implication

May support preferring low-ISI thromboplastin reagents to reduce INR variability in anticoagulation monitoring; leaves open effects on clinical outcomes.

Structured PICO

Population

Plasma samples (87 PT ratio measurements)

Intervention

Mathematical derivative application to INR calculation considering 10 different ISI values ranging from 1.1 to 2

Comparator

Expected values after 1:2 dilution; other systems (prothrombin activity percent, PT seconds, PT ratio)

Outcome

Accuracy of INR and analytical variabilitysurrogate

Using a thromboplastin reagent with an ISI close to 1 reduces the analytical uncertainty of INR measurements in oral anticoagulant therapy monitoring.

Cite This Study

Introcaso et al. (2000) studied this question.

synapsesocial.com/papers/6a6f8ed6febe604dd7087412 https://doi.org/10.1159/000054145

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Implication

May support preferring low-ISI thromboplastin reagents to reduce INR variability in anticoagulation monitoring; leaves open effects on clinical outcomes.

Mathematical Derivative Applied to International Normalised Ratio and Analytical Variations in Oral Anticoagulant Therapy Control

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Mathematical Derivative Applied to International Normalised Ratio and Analytical Variations in Oral Anticoagulant Therapy Control

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider