Favorable Vascular Actions of Angiotensin-(1–7) in Human Obesity
Why the study?
Does intra-arterial infusion of Ang-(1-7) improve vasodilator tone and blunt endothelin-1-dependent vasoconstriction in obese patients?
Population
Obese patients
Comparison
Intra-arterial infusion of Ang-(1-7) (10 nmol/min) vs Saline
Design
Other
Authors
Discussion
Loading...
Member takes
Implication
Exogenous Ang-(1–7) may improve vascular tone in obese humans; leaves open therapeutic potential of Mas agonism.
Structured PICO
Does intra-arterial infusion of Ang-(1-7) improve vasodilator tone and blunt endothelin-1-dependent vasoconstriction in obese patients?
P
Population
Obese patients
I
Intervention
Intra-arterial infusion of Ang-(1-7) (10 nmol/min)
C
Comparator
Saline
O
Outcome
Forearm flow responses to graded doses of acetylcholine and sodium nitroprusside, and response to endothelin A receptor blockadesurrogate
In obese patients, Ang-(1-7) improves insulin-stimulated endothelium-dependent vasodilation and blunts endothelin-1-dependent vasoconstrictor tone, suggesting a potential therapeutic target for obesity-related hemodynamic abnormalities.
Cite This Study
Schinzari et al. (2017) studied this question.