The Changes of Serum-ACE, Plasma Renin Activity and Aldosterone in the Diabetics with Hypertension

It is well known that the serum-ACE levels are elevated in sarcoidosis, Gaucher’s disease, and some granulomatous diseases. Recently, the serum-ACE level was also found to be elevated in diabetes mellitus. To confirm the possible role of plasma renin activity and aldosterone in the pathogenesis of hypertension and to assess the relationship of serum ACE to the plasma renin activity and aldosterone profiles in diabetics, we measured the levels of serum ACE, plasma renin activity, aldosterone and blood pressure in 38 diabetic patients who were admitted to Kyung Hee University Hospital from June 1981 to September, 1982. The results were as follows: The S-ACE activity was significantly elevated in 38 patients with diabetes mellitus (9.42±6.60 Unit) as compared with that in the healthy controls (2.53±1.54 Unit) (p<0.005) (p<0.005).The S-ACE activity was significantly elevated in 15 hypertensive diabetics (14.29± 7.10 Unit) as compared with that in 23 normotensive diabetics (6.24±3.68 Unit) (p<0.005).The S-ACE activity was elevated in 15 diabetic patients with retinopathy (10.6±4.7 Unit) as compared with the levels in 17 diabetic patients without retinopathy (6.7±4.8 U) (p<0.05).The S-ACE activity was directly correlated to the mean arterial pressure (r=0.54) (p<0.005).The plasma renin activity and aldosternone concentrations in diabetics were not different from the normal controls and had no correlationship to the S-ACE activity.After 2 weeks of insulin therapy in 15 diabetics, the S-ACE activity was not changed.